Statistical learning for complex data to enable precision medicine strategies

Zwep, L.B. (2023)

Doctoral Thesis

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients. This thesis discussed multiple aspects of treatment variability and the associated statistical learning techniques which can be used to explain and/or predict part of that variability. Even though in recent times the availability of several high-throughput measurement technologies has created many new opportunities to develop improved treatment strategies, deriving actionable insights from such data remains a challenge. To this end, the use of longitudinal and high-dimensional data analysis techniques is needed to explore omics data for explaining treatment response and clinical course, and to answer clinical questions from routine healthcare data from hospitals and research institutes.

• Statistical learning
• Longitudinal data
• High-dimensional data
• Pharmacometrics
• Precision medicine
• Antibiotic resistance

• All authors: Zwep, L.B.
• Supervisor: Meulman, J.J.
• Co-supervisor: Hasselt, J.G.C. van
• Committee: Irth, H.; Bouwstra, J.A.; Knibbe, C.A.J.; Mentré, F.; Smeden, M. van
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden Academic Centre for Drug Research (LADCR), Faculty of Science, Leiden University
• Date: 2023-04-12
• ISBN (print): 9789493299580