Personalised medicine for multiple outcomes : methods and application

Rüten-Budde, A.J. (2020)

Doctoral Thesis

The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice. The interdisciplinary collaboration between the Mathematical Institute of Leiden University and the Leiden University Medical Center resulted in important contributions to the care of soft tissue sarcoma patients.

• Survival analysis
• Prediction model
• Dynamic prediction
• Multi-state model

• All authors: Rüten-Budde, A.J.
• Supervisor: Eliel, E.; Putter, H.
• Co-supervisor: Fiocco, M.
• Committee: Stevenhagen, P.; Vaart, A.W. van der; Gelderblom, H.; Ieva, F.; Geskus, R.
• Qualification: Doctor (dr.)
• Awarding Institution: Mathematical Institute, Faculty of Science, Leiden University
• Date: 2020-03-10
• Sponsorship: Dutch Cancer Society (DCS) - KWF Kankerbestrijding