Leiden University Scholarly Publications

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Berman-De Jong, E.P. (2019)

Viral infections in young infants : epidemiologic and diagnostic aspects of ToRCH, enterovirus and human parechovirus

Doctoral Thesis
Congenital ‘ToRCH’ infections have a low incidence in The Netherlands but diagnostic testing occurs frequently for a variety of different indications, some of which aren’t necessary. On the contrary, EV- and HPeV infections have a high incidence infants, but are frequently missed due to lack of testing. Furthermore, knowledge about follow-up after a proven infection with EV or HPeV is scarce.
The aim of the first part of this thesis (part A) was to investigate the yield of performing diagnostic tests for ‘ToRCH’ infections in newborn infants with lenticulostriate vasculopathy (LSV) or small for gestational age (SGA). In the second part of this thesis (part B) the epidemiology and follow-up of Entero- (EV) and Human Parechovirus (HPeV) induced sepsis-like illness in neonates and young infants was studied.
This thesis updates and nuances the indications for testing for both groups of pathogens and provides insight in the follow-up after a proven...Show moreCongenital ‘ToRCH’ infections have a low incidence in The Netherlands but diagnostic testing occurs frequently for a variety of different indications, some of which aren’t necessary. On the contrary, EV- and HPeV infections have a high incidence infants, but are frequently missed due to lack of testing. Furthermore, knowledge about follow-up after a proven infection with EV or HPeV is scarce.
The aim of the first part of this thesis (part A) was to investigate the yield of performing diagnostic tests for ‘ToRCH’ infections in newborn infants with lenticulostriate vasculopathy (LSV) or small for gestational age (SGA). In the second part of this thesis (part B) the epidemiology and follow-up of Entero- (EV) and Human Parechovirus (HPeV) induced sepsis-like illness in neonates and young infants was studied.
This thesis updates and nuances the indications for testing for both groups of pathogens and provides insight in the follow-up after a proven infection with EV or HPeV.Show less
Young infants
Sepsis-like illness
ToRCH
Toxoplasmosis
Rubella
Cytomegalovirus
Herpes simplex virus
Enterovirus
Human Parechovirus
Diagnostic testing
All authors
Berman-De Jong, E.P.
Supervisor
Walther, F.J.; Lopriore, E.
Co-supervisor
Brus, F.
Committee
Lankaster, A.C.; Benders, M.J.N.L.; Tutu-van Furth, A.M.
Qualification
Doctor (dr.)
Awarding Institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
Date
2019-10-31
ISBN (print)
9789490791759

Funding

Sponsorship
Chapter 5: Viral typing was made possible through a financial gift from the HAGA Hospital Scientific Fund. Chapters 6 and 7: This study received financial support from the ‘HAGA hospital Scientific Fund’ and a grant from the Foundation ‘Friends of Juliana Children’s hospital’. The printing of this thesis was supported by Willem Alexander Kinderziekenhuis, LUMC, Leiden