Efficacy, safety and novel targets in cardiovascular disease : advanced applications in APOE*3-Leiden.CETP mice

Pouwer, M.G. (2020)

Doctoral Thesis

The thesis discussed several strategies that may contribute to further CVD risk reduction in the future. We described two novel lipid-lowering strategies, we unraveled (part of) the etiology of the cardiovascular safety issues of TKIs that are used for the treatment of CML, and we investigated the dose effects of PFOA on lipoprotein metabolism. Looking forward, we developed a novel mouse model that can be used for the study of diabetic macrovascular complications, and we evaluated the potential of OSM as novel target in CVD.

• Atherosclerosis
• Cholesterol
• Lipoprotein metabolism
• PFOA
• PCSK9
• BCR-ABL1 Tyrosine kinase inhibitors
• Cardiovascular safety
• Oncostatin M
• Cardiovascular Disease
• Translational mouse models

• All authors: Pouwer, M.G.
• Supervisor: Jukema, J.W.
• Co-supervisor: Princen, J.M.G.
• Committee: Rensen, P.C.N.; Bot, I.; Laarse, A. van der; Groen, A.K.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2020-03-05
• ISBN (print): 9789402816396
• Sponsorship: TNO, Metabolic Health Research Daan Traas fonds Pouvet BV CardioGenx