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Metabolic signatures in nutrition and health : short-term diet response, sexual dimorphism and hormone chronobiology
lies in being able to conduct clinical research
on healthy people while capturing metabolic
markers sensitive to the impact of environmental
and metabolic stressors (e.g. diet, changing sex
hormones and the menstrual cycle). Using clinical biomarkers,
metabolomics, and diet interventions with intake analyses,
we demonstrated the metabolic impact of vegan and animal
diet interventions using fasting plasma analysis after 48
hours and using postprandial plasma analysis after meals and
snacks. Sexually dimorphic responses were differentiated using
proteomics and pathway analyses in two larger, sex-balanced
cohorts. Finally, clinical biomarker and metabolomics analyses
identified metabolic subtypes across menstrual cycle phases.
Although challenges with integrating –omics technology and
nutrition remain, the fundamental information generated from
these...Show moreThe power of personalized nutrition
lies in being able to conduct clinical research
on healthy people while capturing metabolic
markers sensitive to the impact of environmental
and metabolic stressors (e.g. diet, changing sex
hormones and the menstrual cycle). Using clinical biomarkers,
metabolomics, and diet interventions with intake analyses,
we demonstrated the metabolic impact of vegan and animal
diet interventions using fasting plasma analysis after 48
hours and using postprandial plasma analysis after meals and
snacks. Sexually dimorphic responses were differentiated using
proteomics and pathway analyses in two larger, sex-balanced
cohorts. Finally, clinical biomarker and metabolomics analyses
identified metabolic subtypes across menstrual cycle phases.
Although challenges with integrating –omics technology and
nutrition remain, the fundamental information generated from
these research studies may provide a foundation for future novel
personalized nutrition strategies.Show less
- All authors
- Draper, C.F.
- Supervisor
- Hankemeier, T.; Greef, J. van der
- Co-supervisor
- Moco, S.
- Committee
- Irth, H.; Bouwstra, J.; Daniel, H.; Brennan, L.; Pijl, H.; Kloet, R. de
- Qualification
- Doctor (dr.)
- Awarding Institution
- Leiden Academic Centre for Drug Research (LACDR) , Faculty of Science , Leiden University
- Date
- 2018-12-20
- ISBN (print)
- 9789492679635
Funding
- Sponsorship
- Nestle Institute of Health Sciences at Nestle Research