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- Part I Cardiovascular system
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Obesity and type 2 diabetes : cardiovascular and cerebral aspects
The prevalence of obesity, defined as a body mass index (BMI) > 30 kg/m2, is increasing to epidemic proportions. In 2014, 11% of men and 15% of women worldwide were obese. Thus, more than half a billion adults worldwide are classed as obese. The fundamental cause of obesity is an imbalance between energy intake (excessive intake of energy-dense foods) and energy expenditure (reduced physical activity). People with obesity are at risk for a range of chronic conditions including cardiovascular disease (CVD) and nonalcoholic fatty liver disease (NAFLD). Furthermore, obesity is a major risk factor for the development of type 2 diabetes, which is one of the most common chronic diseases in nearly all countries. According to the World Health Organization, the global prevalence of diabetes in 2014 was estimated to be 9%, of which 90% was comprised of type 2 diabetes. This thesis focuses on cardiovascular and cerebral dimensions and function in people with obesity and type 2 diabetes. State-of-the-art imaging techniques are used to investigate links between the heart, liver, abdominal fat, and brain to elucidate parts of the complex relationships between these organs.
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- All authors
- Widya, R.L.
- Editor(s)
- Widya R.L.
- Supervisor
- Lamb, H.J.; Roos, A. de; Smit, J.W.A.
- Committee
- Webb, A.; Middeldorp, S.; Wildberger, J.E.; Pijl, H.; Grond, J. van der; Mutsert, R. de
- Qualification
- Doctor (dr.)
- Awarding Institution
- Medicine, Leiden University
- Date
- 2017-09-05
- ISBN (print)
- 9789492683755
Funding
- Sponsorship
- Research was partly performed within the framework of the Center for Translational Molecular Medicine (CTMM; www.ctmm.nl), project PREDICCt (grant 01C-104), and was supported by a grant of the Dutch Heart Foundation (DHF2008-T085), Dutch Diabetes Research Foundation, and Dutch Kidney Foundation. Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged. Additional financial support for the publication of this thesis was kindly provided by Philips Healthcare Nederland, Stichting MiniMAX, Sectra Benelux, Guerbet Nederland BV, Nederlandse Obesitas Kliniek, Tromp Medical BV, Oldelft Benelux, Toshiba Medical Systems Nederland, Alrijne Zorggroep, Sanofi Nederland, Medis medical imaging systems BV, Esaote Europe BV, and ChipSoft.