An engineering approach to decode immune responses

Bresser, K. (2023)

Doctoral Thesis

Throughout this thesis, I have endeavored to apply an engineer’s mindset in my pursuit to better understand the marvelously convoluted immune system. In doing so, my colleagues and I have generated a number of new ‘hardware’
(i.e., genetically engineered) tools and ‘software’ modules (i.e., custom analyses and models) that enable the investigation of several otherwise difficult-to- study concepts. Although we have used these modules here to study immune responses, I hope they may be utilized as tools and approaches to crack outstanding questions in other fields of research.

• Adaptive immunity
• Oncoimmunology
• Genetic engineering
• Transcriptomics

• All authors: Bresser, K.
• Supervisor: Schumacher, A.N.M.
• Co-supervisor: Scheeren, F.A.
• Committee: Neefjes, J.J.C.; Kasteren, S.I. van; Keyser-Borst, J.; Amsen, D.; Wolkers, M.C.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2023-11-15
• ISBN (print): 9789464834932