To fail or not to fail : clinical trials in depression

Sante, G.W.E. (2008)

Doctoral Thesis

To fail or not to fail __ Clinical trials in depression investigates the causes of the high failure rate of clinical trials in depression research. Apart from the difficulties in the search for new antidepressants during drug discovery, faulty clinical trial designs hinder their evaluation during drug development. This thesis focuses on three important aspects of clinical trials in depression: clinical endpoints, data analysis and trial design-related factors.

• Antidepressants
• Bayesian statistics
• Clinical trials
• Clinical trial simulation
• Depression
• Efficacy trials
• HAMD
• Hamilton
• Interim analysis
• SSRI

• All authors: Sante, G.W.E.
• Supervisor: Danhof, M.
• Co-supervisor: Della Pasqua, O.E.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Science, Leiden University
• Date: 2008-09-10
• ISBN (print): 9789085593775