Clinical outcomes of modern lamellar keratoplasty techniques

Dijk, K. van (2018)

Doctoral Thesis

After penetrating keratoplasty had been the preferred method for the treatment of corneal disorders for almost a century, the introduction of lamellar keratoplasty techniques has changed the field of corneal transplantation substantially over the last two decades. These lamellar keratoplasty techniques provide several advantages over penetrating keratoplasty: anterior lamellar keratoplasty may potentially improve graft survival by preserving the healthy recipient endothelium in the management of corneal stromal diseases, and endothelial keratoplasty has improved the predictability and speed of visual rehabilitation for treating endothelial disorders, mainly by leaving the anterior corneal surface intact.
The latest innovation in the field of endothelial keratoplasty is Descemet membrane endothelial keratoplasty (DMEK), in which only the Descemet membrane and endothelium are replaced by donor tissue.
The trend towards more selective and minimally invasive transplantation techniques has also led to the development of new treatment options for patients with (advanced) keratoconus, including the mid-stromal implantation of an isolated donor Bowman layer, referred to as Bowman layer-transplantation.
This thesis focusses on the feasibility and clinical outcomes of these two modern lamellar keratoplasty techniques, i.e. DMEK for endothelial disorders, and Bowman layer-transplantation for advanced keratoconus.

• DMEK
• Desecmet membrane endothelial keratoplasty
• Bowman layer transplantation
• Fuchs endothelial dystrophy
• Bullous keratopathy
• Keratoconus

• All authors: Dijk, K. van
• Supervisor: Jager, M.J.
• Co-supervisor: Melles, G.R.J.
• Committee: Koppen, C.; Imhof, S.M.; Cheng, Y.Y.
• Qualification: Doctor (dr.)
• Awarding Institution: Medicine / Leiden University Medical Center (LUMC), Leiden University
• Date: 2018-01-16
• ISBN (print): 9789463610261