Blood and Biomarkers in Huntington's Disease

Mastrokolias, A. (2017)

Doctoral Thesis

The work described in this thesis presents part of a framework that can be used to extract
detailed disease biological information from peripheral tissue. This framework is based
on the central dogma of biology “DNA to RNA to protein” and on a systems biology
approach that aims to produce synergetic data whose disease pathological, prognostic
and predictive value is greater than the sum of the individual experiment results. HD
patients are often characterized by a multifaceted clinical profile, consisting of several
symptoms and variable disease progression rates. Therefore, a systems approach such as
the one described above is expected to be the most effective in identifying potential treatments
and predictive biomarkers that will be most informative for the different patient
subpopulations.

• Biomarkers
• Gene expression
• Metabolomics
• Peripheral blood
• Neurodegenerative disease

• All authors: Mastrokolias, A.
• Supervisor: Ommen, G.J.B. van
• Co-supervisor: Roon-Mom, W.M.C. van
• Committee: Dunnen, J.T. den; Meijer, O.C.; Kampinga, H.H.; Hoen, P.A.C. 't; Dorsman, J.C.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2017-09-07
• ISBN (print): 9789463321952