Modulation of estrogen signaling in hepatic and vascular tissue

Krom, Y.D. (2006)

Doctoral Thesis

This thesis centers on the mechanisms of estrogen action and the effects on the development of atherosclerosis. We have focused on the liver as central organ in lipid and glucose metabolism and the vessel wall as the actual site where the injury occurs. To gain insight in tissue-specific actions of estrogens, we have spent considerable effort to develop tools for liver and blood vessel specific modulation of the estrogen receptor (ER) signaling cascade. The generation, characterization and application of these tools in vitro and in vivo will be described in the different chapters of this thesis.

• Atherosclerosis
• Adenovirus
• Estrogen
• Liver
• Neointima formation
• SiRNA
• Targeting
• Vascular

• All authors: Krom, Y.D.
• Supervisor: Havekes, L.M.
• Co-supervisor: Willems, van Dijk, K.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2006-11-07
• ISBN (print): 9789090211381
• Court: LEI Universiteit Leiden
• Sponsorship: Dr. ir. Van de Laar Stichting J.E. Juriaanse Stichting