Characteristics and clinical outcomes of mucosal melanoma

Boer, F.L. (2024)

Doctoral Thesis

Mucosal melanomas (MM) are malignant tumours arising from melanocytes located at the mucosal lining of the head and neck region or the respiratory, gastrointestinal, anorectal, or genital tract. Due to the low incidence the disease is still poorly understood and management is mostly based on guidelines of cutaneous melanoma (CM). Survival of patients with MM is poor and regardless of stage is worse than that of CM. This is explained by the advanced stage at diagnosis and high recurrence rates of MM. Moreover, whilst immunotherapeutic agents have revolutionized the therapeutic landscape in CM, in MM, the efficacy is low and survival has not improved since the introduction of these therapies.
The MM located at the vulva (VMM) account for 60% of the female genital tract MM and together with the head and neck region are the most common locations of MM. In line with the MM located at all other locations, prognosis is poor. Whilst the majority of the patients is diagnosed with local disease, the aggressive course of disease is demonstrated by the high recurrence rates with short time to recurrence with a median overall survival of 33 months. To improve outcomes in MM, there is a critical need for clinical trials specifically designed for this disease and international collaboration.

• Mucosal melanoma
• Vulvar melanoma
• Survival
• Immunotherapy

• All authors: Boer, F.L.
• Supervisor: Blank, C.U.
• Co-supervisor: Kapiteijn, H.W.; Poelgeest, M.I.E. van
• Committee: Smit, V.T.H.B.M.; Hage, J.A. van der; Gelderblom, A.J.; Suijkerbuijk, K.P.M.; Hullu, J.A. de
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2024-03-19
• ISBN (print): 9789464960228
• Sponsorship: ABN Amro; Chipsoft