Leiden University Scholarly Publications

Persistent URL of this record https://hdl.handle.net/1887/3571838

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Hout, M.J.P. van (2023)

Advanced MRI in aortic pathology and systemic interactions

Doctoral Thesis
Cardiovascular disease is the leading cause of death in the world. Therefore, there is an increasing need for accurate and efficient cardiovascular risk assessment to optimize cardiovascular treatment. The aorta plays a central role in the cardiovascular system, transporting blood to various organ systems while absorbing the pulsatile pressure of the cardiac output. Aortic stiffness is a marker of vascular aging and has shown to be an independent marker for cardiovascular risk. Additionally, enlarged aortic dimensions are linked to an increased risk of rupture. MRI is capable of providing accurate information on aortic morphology, stiffness and blood flow patterns.
In this thesis we expanded the potential clinical utility of MRI-based measures of aortic morphology and function in the assessment of cardiovascular risk and further unravelled complex cardiovascular systemic interactions using MRI. We provided standardized methods and reference values for fundamental MRI-based...Show moreCardiovascular disease is the leading cause of death in the world. Therefore, there is an increasing need for accurate and efficient cardiovascular risk assessment to optimize cardiovascular treatment. The aorta plays a central role in the cardiovascular system, transporting blood to various organ systems while absorbing the pulsatile pressure of the cardiac output. Aortic stiffness is a marker of vascular aging and has shown to be an independent marker for cardiovascular risk. Additionally, enlarged aortic dimensions are linked to an increased risk of rupture. MRI is capable of providing accurate information on aortic morphology, stiffness and blood flow patterns.
In this thesis we expanded the potential clinical utility of MRI-based measures of aortic morphology and function in the assessment of cardiovascular risk and further unravelled complex cardiovascular systemic interactions using MRI. We provided standardized methods and reference values for fundamental MRI-based measures of aortic morphology and function, explored new methods to make PWV more accessible, evaluated the prognostic value of MRI-based measures of aortic morphology and function and explored systemic interactions of cardiovascular function with obesity as well as the brain. These studies contribute to more accurate and accessible cardiovascular risk assessment, which eventually can lead to improved cardiovascular treatment.
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Cardiovascular disease
Aortic pathology
Pulse wave velocity
Vascular stiffness
Magnetic resonance imaging
All authors
Hout, M.J.P. van
Supervisor
Lamb, H.J.; Schalij, M.J.
Co-supervisor
Scholte, A.J.H.A.
Committee
Jukema, J.W.; Bluemke, D.A.; Wildberger, J.E.; Mutsert, R. de; Hjortnaes, J.
Qualification
Doctor (dr.)
Awarding Institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
Date
2023-03-16
ISBN (print)
9789464692495

Funding

Sponsorship
Hart Onderzoek Nederland; ChipSoft; Pie Medical Imaging; Dutch Heart Foundation