Towards the development of synthetic vaccines against tuberculosis

Marino, L. (2022)

Doctoral Thesis

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery. A variety of synthetic analogues of mycobacterial cell wall components, from peptide and glycolipid antigens to glycolipid PAMPs has been accessed. Evaluation of the immune stimulatory activity of the novel compounds in combination with preliminary immunization studies in vivo, suggested the potential of selected synthetic conjugates as single molecule vaccines against TB. Further research is needed to verify the efficacy of these vaccine modalities.

• Mycobacterium tuberculosis
• Synthetic conjugates
• Vaccines
• Phosphomycoketide analogues
• Trehalose dimycolate analogues
• Glucose monomycolate analogues
• Mincle
• Upam
• TLR2

• All authors: Marino, L.
• Supervisor: Codée, J.D.C.; Ottenhoff, T.H.M.
• Committee: Marel, G.A. van der; Rhijn, I. van; Geluk, A.; Filippov, D.V.; Minnaard, A.J.
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University
• Date: 2022-06-07
• ISBN (print): 9789493289017