Persistent URL of this record https://hdl.handle.net/1887/3303689
Documents
-
- Download
- Title pages_Contents
- open access
-
- Download
- Chapter 2
- open access
- Full text at publishers site
-
- Download
- Chapter 3
- open access
- Full text at publishers site
-
- Download
- Chapter 4
- open access
- Full text at publishers site
-
- Download
- Chapter 6
- open access
- Full text at publishers site
-
- Download
- Summary in English
- open access
-
- Download
- Summary in Dutch
- open access
-
- Download
- Curriculum Vitae_Acknowledgements
- open access
-
- Download
- Propositions
- open access
In Collections
This item can be found in the following collections:
Personalized medicine in rheumatoid arthritis
Show moreRheumatoid arthritis (RA) is a chronic, symmetrical, autoimmune disease characterized by inflammation of the joints, as well as damage to a variety of body systems, including the skin, eyes, lungs, heart and blood vessels. Therefore, to prevent (potential) damage with a more favorable course of the disease, it is important to intervene both early and agressively with medication in the treatment of RA. Typically, methotrexate is used as the first treatment, possibly in conjuction with other disease-modifying antirheumatic drugs, or with prednisolone to reduce inflammation rapidly. While the treatment of RA has improved considerably in recent decades, drug treatment does not work for everyone due to toxicity or lack of responsiveness. Therefore, it is suspected that genetics plays a major role in the both efficacy and toxicity of current RA medication. The goal of this thesis is to identify the genetic factors that influence the effectiveness or toxicity of the drugs used in RA.
Show less
- All authors
- Eektimmerman, F.
- Supervisor
- Guchelaar, H.J.
- Co-supervisor
- Swen, J.J.; Allaart, C.F.
- Committee
- Gelder, T. van; Helm-van Mil, A.H.M. van der; Roon, E.N. van; Kosterink, J.G.W.; Teichert, M.
- Qualification
- Doctor (dr.)
- Awarding Institution
- Faculty of Medicine, Leiden University Medical Center (LUMC) , Leiden University
- Date
- 2022-05-11
- ISBN (print)
- 9789490791896