Leiden University Scholarly Publications

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Onderwater, G.L.J. (2022)

Biochemistry in different phases of the migraine attack

Doctoral Thesis
This thesis aimed to explore biochemical processes related to migraine outside (interictal) and during upcoming attacks. Chapter 2 describes the biochemical profiling of plasma samples from interictal migraine patients and healthy controls from eight Dutch cohorts with a proton nuclear magnetic resonance based metabolomics platform. In Chapter 3 cerebrospinal fluid (CSF) and plasma samples from interictal migraine with and without aura patients and healthy volunteers, were profiled using an ultra-performance liquid chromatography mass spectrometry (UPLC-MS) platform for amine measurements, as multiple amines have been implicated in migraine pathophysiology. Alcoholic beverages are frequently reported migraine triggers. Chapter 4 assessed the potential of various alcohol beverages as a migraine attack trigger using a questionnaire study in a large cohort of migraine patients. In Chapter 5, the frequently used pharmacological migraine trigger glyceryl trinitrate (GTN) was studied...Show moreThis thesis aimed to explore biochemical processes related to migraine outside (interictal) and during upcoming attacks. Chapter 2 describes the biochemical profiling of plasma samples from interictal migraine patients and healthy controls from eight Dutch cohorts with a proton nuclear magnetic resonance based metabolomics platform. In Chapter 3 cerebrospinal fluid (CSF) and plasma samples from interictal migraine with and without aura patients and healthy volunteers, were profiled using an ultra-performance liquid chromatography mass spectrometry (UPLC-MS) platform for amine measurements, as multiple amines have been implicated in migraine pathophysiology. Alcoholic beverages are frequently reported migraine triggers. Chapter 4 assessed the potential of various alcohol beverages as a migraine attack trigger using a questionnaire study in a large cohort of migraine patients. In Chapter 5, the frequently used pharmacological migraine trigger glyceryl trinitrate (GTN) was studied in migraine patients and healthy controls to investigate whether previously reported premonitory symptoms are indeed specific to migraine patients. In Chapter 6 glutamate, glutamine, and GABA were assed in the visual cortex of migraine patients before and over the course of a GTN-provoked attack to detect possible involvement of the glutamatergic system in the onset of attacks using proton magnetic resonance spectroscopy.
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Migraine
Cerebrospinal fluid
Magnetic resonance spectroscopy
Glutamate
GABA
Metabolomics
HDL
Arginine
Ethanol
Glyceryl trinitrate
All authors
Onderwater, G.L.J.
Supervisor
Terwindt, G.M.; Ferrari, M.D.; Maagdenberg, A.M.J.M.van den
Committee
Verschuuren, J.J.G.M.; Penninx, B.W.J.H.; Willems van Dijk, J.A.P.; Klomp, D.W.J.
Qualification
Doctor (dr.)
Awarding Institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
Date
2022-04-21
ISBN (print)
9789464194548

Funding

Sponsorship
Netherlands Organization for Scientific Research (VICI grant 918.56.601 and Spinoza 2009), the Netherlands Organization for Health Research and Development (Clinical Fellowship 90700217 and VIDI grant 917.11.31 ), and European Community (EC) FP7-EUROHEADPAIN—no. 602633). Funding for publication of this thesis has been provided by the Nederlandse Hoofdpijn Vereniging