Cardiac and vascular alpha(1)-adrenoceptors in congestive heart failure: a systematic review

Kayki-Mutlu, G.; Papazisi, O.; Palmen, M.; Danser, A.H.J.; Michel, M.C.; Arioglu-Inan, E.

doi:doi:10.3390/cells9112412

As heart failure (HF) is a devastating health problem worldwide, a better understanding and the development of more effective therapeutic approaches are required. HF is characterized by sympathetic system activation which stimulates alpha- and beta-adrenoceptors (ARs). The exposure of the cardiovascular system to the increased locally released and circulating levels of catecholamines leads to a well-described downregulation and desensitization of beta-ARs. However, information on the role of alpha-AR is limited. We have performed a systematic literature review examining the role of both cardiac and vascular alpha(1)-ARs in HF using 5 databases for our search. All three alpha(1)-AR subtypes (alpha(1A), alpha(1B) and alpha(1D)) are expressed in human and animal hearts and blood vessels in a tissue-dependent manner. We summarize the changes observed in HF regarding the density, signaling and responses of alpha(1)-ARs. Conflicting findings arise from different studies concerning the...Show moreAs heart failure (HF) is a devastating health problem worldwide, a better understanding and the development of more effective therapeutic approaches are required. HF is characterized by sympathetic system activation which stimulates alpha- and beta-adrenoceptors (ARs). The exposure of the cardiovascular system to the increased locally released and circulating levels of catecholamines leads to a well-described downregulation and desensitization of beta-ARs. However, information on the role of alpha-AR is limited. We have performed a systematic literature review examining the role of both cardiac and vascular alpha(1)-ARs in HF using 5 databases for our search. All three alpha(1)-AR subtypes (alpha(1A), alpha(1B) and alpha(1D)) are expressed in human and animal hearts and blood vessels in a tissue-dependent manner. We summarize the changes observed in HF regarding the density, signaling and responses of alpha(1)-ARs. Conflicting findings arise from different studies concerning the influence that HF has on alpha(1)-AR expression and function; in contrast to beta-ARs there is no consistent evidence for down-regulation or desensitization of cardiac or vascular alpha(1)-ARs. Whether alpha(1)-ARs are a therapeutic target in HF remains a matter of debate.Show less

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Cardiac and vascular alpha(1)-adrenoceptors in congestive heart failure: a systematic review