Molecular characterization of pathogenic Clostridium difficile strains

Bakker, D. (2014)

Doctoral Thesis

Over the last years major advances have been made in the field of C. difficile research. Despite the continuous progress of research in C. difficile epidemiology and molecular biology. This thesis shows that the development of molecular based techniques in detecetion and typing of C. difficile could be very valuable in combatting CDI. This also applies for the genetics and molecular biology of C. difficile in understanding the virulence of C. difficile. However, the continuing development of new techniques, both typing and genetics manipulation tools, has also led to the recognition of potential weaknesses of the currently frequent used techniques. Therefore, it is of utmost importance to keep up with the technical progress in the field of C. difficile research to enable further elucidation of the mechanisms that determine the virulence of C. difficile.

• Typing
• Toxin regulation
• Molecular
• Clostridium difficile

• All authors: Bakker, D.
• Supervisor: Kuijper, E.J.
• Co-supervisor: Corver, J.; Smits, W.K.
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden University Medical Center (LUMC), Leiden University
• Date: 2014-11-05
• ISBN (print): 9789490858322