Exploring and modulating the tumor immune microenvironment: Towards improving patient outcomes of immunotherapy in lung cancer

Theelen, W.S.M.E. (2020)

Doctoral Thesis

This thesis sought to obtain a better understanding of the composition of the immune microenvironment in NSCLC and how to modulate this tumor immune microenvironment by RT to induce amplified antitumor immune responses to ICIs in advanced NSCLC patients. In the first part of this thesis, a multiangular approach of a combination of protein and mRNA expression with clinicopathological characteristics in a large cohort of early stage, resected NSCLC samples will be discussed. The second part focusses on the immune modulating effects of RT, in particular when combined with immunotherapy treatment in metastatic NSCLC.

• NSCLC
• Gene expression
• PD-L1
• Immunotherapy
• Radiotherapy
• Abscopal effect

• All authors: Theelen, W.S.M.E.
• Supervisor: Baas P., Heuvel M.M. van den
• Committee: Marijnen, C.A.M.; Keyser-Borst, J.G.; Hiemstra, P.S.; Hoeven, J.J.M. van der; Ruysscher, D.K.M. de; Becker-Commissaris, A.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2020-10-21
• ISBN (print): 9789464230109