Genetic and environmental determinants of cardiometabolic health

Bos, M.M. (2020)

Doctoral Thesis

Cardiovascular disease and diabetes are one of the leading causes of death worldwide. Multiple genetic and non-genetic factors play a role in this process. This dissertation aims to study the interplay between genetic factors and lifestyle factors (eg sleep, nutrition, physical activity) with diseases such as cardiovascular disease and risk factors for cardiovascular disease (diabetes). For example, 12 blood biomarkers associated with insulin resistance have been identified, 5 of which are specifically much higher in subjects with diabetes. In addition, it appeared that a short sleep duration and poor sleep quality are associated with poorer lipids in the blood (eg cholesterol and LDL) and more insulin resistance. With regard to sleep, 59 new genetic variants have also been identified with regard to blood lipids (HDL, LDL, triglycerides). In addition, the results indicate that a better lifestyle can also help reduce the development of new cardiovascular diseases in people with an increased genetic risk. This is particularly interesting to prevent diseases in persons at high risk. All in all, this thesis has provided new insights into the various factors that are potentially important in the development of cardiovascular disease and diabetes.

• Cardiovascular disease
• Diabetes
• Insulin resistance
• Metabolomics
• Genomics
• Lifestyle

• All authors: Bos, M.M.
• Supervisor: Blauw, G.J.
• Co-supervisor: Heemst, D. van; Noordam, R.
• Committee: Rensen, P.C.N.; Parini, P.; Rutters, F.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2020-10-01
• ISBN (print): 9789463614610