Respiratory tract infection: prevention, early detection and attenuation of immune response

Groeneveld, G.H. (2020)

Doctoral Thesis

Different aspects of respiratory tract infection have been studied. Automatic syndromic surveillance for early detection of infections is feasible. Peak in ILI in hospitals is most flu seasons before rise in cases in primary care. Influenza vaccination can safely be given to oncology patients who use checkpoint inhibitors. we were unable to demonstrate an attenuation of immune response in patients treated with non-lytic rifampicin for pneumococcal pneumonia. Cardiac surgery during influenza season is a risk factor for postoperative ARDS.

• Respiratory tract infection
• Pneumonia
• Influenza
• Vaccination
• Surveillance
• Immune response
• ARDS

• All authors: Groeneveld, G.H.
• Supervisor: Dissel, J.T. van
• Co-supervisor: Steenbergen, J.E. van
• Committee: Bel, E.H.D.; Jong, M.D. de; Jonge, E. de; Visser, L.G.; Numans, M.E.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2020-03-11
• ISBN (print): 9789463613927
• Sponsorship: Financial support for the clinical studies by The Netherlands Organisation for Health Research and Development, ZonMW [grant number 204000001], by the Virgo consortium, funded by the Dutch government [grant number FES0908], the Netherlands Genomics Initiative (NGI) [grant number 050-060-452], and the Franje Foundation is gratefully acknowledged.