Lessons learnt about two-year follow-up in hand osteoarthritis: the HOSTAS study.

Damman, W.

Persistent URL of this record https://hdl.handle.net/1887/72577

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Damman, W. (2019)

Lessons learnt about two-year follow-up in hand osteoarthritis: the HOSTAS study.

Doctoral Thesis

Studies in this thesis were performed in a secondary care cohort of patients with hand osteoarthritis. Several factors were investigated for their association with disease status and disease progression after two years. These factors included comorbidity, illness perceptions and MRI-defined inflammatory features such as bone marrow lesions, synovitis and joint effusion. In the MRI studies we found that these MRI-features have a clinically relevant role for their association with pain (at the same moment and after two years) and progression of radiographic damage after two years. In the second part of this thesis we evaluated the clinimetric properties of two new instruments: self-reported painful joint count and semi-automatic joint space width measurements.