On cerebral lupus: from pathogenesis to clinical outcomes

Magro Checa, C. (2019)

Doctoral Thesis

In this thesis we have analyzed an important number of laboratory, radiological, clinical and patient´s reported outcomes in systemic lupus erythematosus (SLE) patients presenting with neuropsychiatric (NP) manifestations. Our studies are among the most robust to date in this field due to the large number of patients included, the prospective character and the standard assessment followed by a multidisciplinary expert consensus.

Furthermore our studies include the novelty of a phenotypic characterization of all NP manifestations according to the suspected underlying pathophysiological mechanism (inflammation or immune-mediated vs. ischemic or thrombotic). These studies give more light to the understanding of the underlying pathophysiological mechanisms of nervous involvement in SLE.

• Lupus
• Neuropsychiatric
• Brain
• Neuroradiology
• Autoimmunity
• Complement
• SF-36
• Antibody
• MRI

• All authors: Magro Checa, C.
• Supervisor: Huizinga, T.W.J.; Buchem, M.A. van
• Co-supervisor: Steup-Beekman, G.M.
• Committee: Middelkoop, H.A.M.; Voskuyl, A.; Eikenboom, J.; Bortoluzzi, A.; Trouw, L.A.
• Qualification: Doctor (dr.)
• Awarding Institution: Rheumatology, Medicine / Leiden University Medical Center (LUMC), Leiden University
• Date: 2019-05-09
• ISBN (print): 9789090316079