Exploring the world of non-coding genes in stem cells and autoimmunity.

Messemaker, T.C. (2018)

Doctoral Thesis

Numerous studies have contributed to our current understanding of autoimmune diseases (AIDs), however, pathogenesis of many AIDs can still not be fully explained. Both genetic factors and environmental factors are involved in the onset of autoimmunity. Which mechanisms explain the contribution of these genetic and environmental factors to disease pathogenesis, and how the different factors interplay remain unanswered key questions. The studies presented in this thesis aimed at identifying and unravelling some of the enigmatic mechanisms in rheumatoid arthritis (RA) and systemic sclerosis (SSc).

• Non-coding RNAs
• Genetics
• Epigenetics
• Rheumatoid arhtitis
• Systemic sclerosis
• Sox2

• All authors: Messemaker, T.C.
• Supervisor: Toes, R.E.M.
• Co-supervisor: Kurreeman, B.A.S.; Mikkers, H.M.M.
• Committee: Huizinga, T.W.J.; Hoeben, R.C.; Gribnau, J.H.; Zhernakova, A.P.
• Qualification: Doctor (dr.)
• Awarding Institution: Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2018-04-03
• ISBN (print): 9789402809596