Leiden University Scholarly Publications

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Hoogendam, J. (2006)

The role of PTHrP in chondrocyte differentiation.

Doctoral Thesis
Longitudinal growth is the key characteristic that distinguishes children from adults. Growth is regulated in the growth plates, which are layers of cartilage located at the ends of the long bones. The cartilage cells are called chondrocytes and go through a coordinated program of proliferation, maturation, hypertrophic differentiation, apoptosis and replacement by bone. This process is called endochondral bone formation. A complex network of hormones (endocrine regulators) is involved in this process. The mechanism of actions of these hormones is not completely understood. A possible mechanism of action is the interaction of systemic hormones with locally produced growth factors (paracrine regulators), like the Parathyroid Hormone (PTH) related Peptide (PTHrP) and its receptor, the type 1 PTH/PTHrP receptor (PTHR1). PTHrP and PTHR1 are among the key regulators in the process of endochondral bone formation. The working mechanism of PTHrP signalling, alone or in combination with...Show moreLongitudinal growth is the key characteristic that distinguishes children from adults. Growth is regulated in the growth plates, which are layers of cartilage located at the ends of the long bones. The cartilage cells are called chondrocytes and go through a coordinated program of proliferation, maturation, hypertrophic differentiation, apoptosis and replacement by bone. This process is called endochondral bone formation. A complex network of hormones (endocrine regulators) is involved in this process. The mechanism of actions of these hormones is not completely understood. A possible mechanism of action is the interaction of systemic hormones with locally produced growth factors (paracrine regulators), like the Parathyroid Hormone (PTH) related Peptide (PTHrP) and its receptor, the type 1 PTH/PTHrP receptor (PTHR1). PTHrP and PTHR1 are among the key regulators in the process of endochondral bone formation. The working mechanism of PTHrP signalling, alone or in combination with other growth factors or systemic hormones, in endochondral bone formation is not completely understood. In this thesis, we have further addressed the actions of PTHrP in the complex network of endocrine and paracrine regulation of endochondral bone formation.Show less
ATDC5 cell line
BOCD
cDNA microarray
Chondrocytes
Growth plate
Nherf
PTHR1
PTHrP
qPCR
All authors
Hoogendam, J.
Supervisor
Wit, J.M.
Co-supervisor
Karperien, H.B.J.
Qualification
Doctor (dr.)
Awarding Institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
Date
2006-12-06
Publisher
Wageningen: Ponsen & Looijen b.v.
ISBN (print)
9789064640285

Juridical information

Court
LEI Universiteit Leiden

Funding

Sponsorship
Netherlands Organization of Scientific Research (NWO), department of Paediatrics of the LUMC, Nederlandse Vereniging van Calcium en Botstofwisseling (NVCB)