Persistent URL of this record https://hdl.handle.net/1887/49260
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- Title page_Contents
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- Chapter 2
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- Chapter 3
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- Chapter 5
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- Chapter 8 Discussion and final conclusions
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- Summary in Dutch
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- Curriculum Vitae_List of publications
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- Propositions
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Challenging the cholinergic system : ageing, cognition & inflammation
This thesis describes several state-of-the-art challenge methods to study the cholinergic system in humans by measuring the effects of compounds that selectively act upon muscarinic or nicotinic acetylcholine receptors. The thesis reveals part of the complexity of the cholinergic system, its changes related to aging, its relationship with cognitive function and performance, and its role in inflammation. Additionally, the methodology described in the thesis provides controlled circumstances using repeated measurement of drug concentrations and effects during a pharmacologic cholinergic challenge that can be used in drug development of new compounds with cholinergic activity.
- All authors
- Alvarez-Jiménez, R.
- Supervisor
- Gerven, J.M.A. van; Cohen, A.F.
- Co-supervisor
- Groeneveld, G.J.
- Committee
- Danhof, M.; Blauw, G.J.; Maelicke, A.; Doef, T. van der
- Qualification
- Doctor (dr.)
- Awarding Institution
- Medicine, Leiden University
- Date
- 2017-06-01
Funding
- Sponsorship
- Centre for Human Drug Research (CHDR), Leiden, the Netherlands