Immunological aspects of conventional and new treatments for cervical cancer, an immunopharmacological approach

Meir, H. van (2017)

Doctoral Thesis

Conventional therapies as chemotherapy and radiotherapy impact immune populations and immune responses in cervical cancer patients. This led to new perspectives into the important role of the immune system and possibilities to optimally implement immunotherapy in the treatment of cervical cancer. Immunotherapy with HPV16-SLP vaccination is a suitable candidate for combined therapy with chemotherapy, when administered within the optimal time window, as it maximizes vaccination efficacy while tumor-induces immune suppression is tackled. To eventually improve clinical outcome in cervical cancer patients, multimodality treatment approaches need further exploration. Within that approach, the assignment of treatment dose, timing and route of administration of both immunotherapy and the classic conventional therapies are important. In addition, individualization of patients therapy based on immune markers prior to treatment should be a goal to optimize combination therapy, minimize side effects and improve clinical outcomes. 

• Immunotherapy
• Combined chemo-immunotherapy
• Cervical cancer
• HPV16-SLP vaccination
• Immunomonitoring

• All authors: Meir, H. van
• Supervisor: Burg, S.H. van der; Burggraaf, J.; Kenter, G.G.
• Co-supervisor: Poelgeest, M.I.E. van
• Committee: Creutzberg, C.L.; Nijman, H.W.; Haanen, J.B.A.G.
• Qualification: Doctor (dr.)
• Awarding Institution: Medicine, Leiden University
• Date: 2017-04-12