Persistent URL of this record https://hdl.handle.net/1887/46406
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Unraveling mechanisms of vascular remodeling in arteriovenous fistulas for hemodialysis
access suffers from a high number of failures responsible for a high morbidity and health care costs. However, the exact pathophysiology remains unclear. In order to unravel the mechanisms of arteriovenous fistula failure we developed a novel murine model of arteriovenous fistula failure. Using this model, we studied the effects of vascular remodeling in mice that were haplodeficient for the eln gene. The role of inflammation in arteriovenous remodeling was also investigated by administrating liposomal prednisolone and by incorporating RP105 knockout mice.
- All authors
- Wong, C.Y.
- Supervisor
- Rabelink, A.J.; Quax, P.H.A.
- Co-supervisor
- Rotmans, J.I.
- Committee
- Bogt, K.E.A. van der; Verhagen, H.J.M.; Vries, C.J.M. de; Hamming, J.F.
- Qualification
- Doctor (dr.)
- Awarding Institution
- Faculty of Medicine, Leiden University Medical Center (LUMC) , Leiden University
- Date
- 2017-03-08
- ISBN (print)
- 9789492332189
Funding
- Sponsorship
- Nederlandse hartstichting, Krijnen medical, Alrijne zorggroep, Astellas Pharma, Fresenius Medical Care, Enceladus Pharmaceuticals en Chipsoft