Charting the dynamic methylome across the human lifespan

Slieker, R. (2017)

Doctoral Thesis

In this thesis we aimed to get insight in how the methylome is established during development
and subsequently degenerates during ageing using an integrative approach to the analysis of
DNA methylation in conjunction with other levels of genomics data. The first two empirical
chapters of this thesis describe the establishment and the maintenance of the epigenome during fetal development and in later life in multiple tissues. In the subsequent two chapters we investigated the loss of control over the methylome in blood and other tissues.

 

• DNA methylation
• Ageing
• Development
• Tissues

• All authors: Slieker, R.
• Supervisor: Slagboom, P.E.
• Co-supervisor: Heijmans, B.T.
• Committee: Goeman, J.J.; Rots, M.G.; Haan, G. de
• Qualification: Doctor (dr.)
• Awarding Institution: Medicine, Leiden University
• Date: 2017-02-09
• ISBN (print): 9789462335103