Circulating gut-associated antigens of Schistosoma mansoni : biological, immunological, and molecular aspects

Dam, G.J. van (1995)

Doctoral Thesis

Human schistosomiasis (bilharzia) is one of the major parasitic diseases in the world, affecting 200 million people predominantly in third world countries. In areas where the disease is highly prevalent it causes important health problems, and it also has socially-economic effects on the population. Schistosomiasis is caused by the presence of the blood-fluke Schistosoma in the blood-vessels of mammalian hosts. The current method for diagnosis of schistosomiasis in developing countries is the parasitological examination of urine and faeces for the presence of Schistosoma eggs. An alternative method which is now increasingly used is based on the detection of Schistosoma antigens in the circulatory system or the urine of the host. The gut of the parasite is an important source of these antigens since many gut-associated antigens are excreted into the circulation of the host following digestion of food (e.g. blood cells, proteins) by the parasite. Two major gut–associated antigens which have been thoroughly studied with regard to diagnostic detectability, are the circulating anodic antigen (CAA) and the circulating cathodic antigen (CCA). In this thesis, these two unique antigens are further analysed with respect to their biochemical carbohydrate structure, localization, in vitro and in vivo excretion and detection patterns, and their role in a number of host-parasite immune interactions (granulocytes, complement system).

• Schistosomiasis
• Immunology
• Glycobiology
• Diagnosis
• Host-parasite relationship
• Circulating antigens
• CAA
• CCA

• All authors: Dam, G.J. van
• Supervisor: Supervisor: A.M. Deelder Co-Supervisor: J.P. Rotmans
• Qualification: Doctor (dr.)
• Date: 1995-02-09
• ISBN (print): 9090077960