Leiden University Scholarly Publications

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Zoni, E. (2016)

Novel regulators of prostate cancer stem cells and tumor aggressiveness

Doctoral Thesis
In the past decade it became increasingly clear that tumor heterogeneity represents one of the major problems for cancer treatment, also in prostate cancer. The identification of the molecular properties of highly aggressive cells (Cancer Stem Cells, CSCs) dispersed within the tumor represents a challenge for the identification of new efficient therapies. In most of the cases, current treatments are indeed successful in eradicating the primary tumor. However, the clinical evidence of relapse and the occurrence of therapy resistance, suggest the presence of subpopulation of cells within the tumor, that can survive such treatments and can perpetuate the cancer. In this thesis we investigated the molecular properties of selected highly aggressive CSCs and indentified novel modulators responsible for the maintenance of their aggressive behavior. Collectively, the studies described in this thesis have increased our insights into the molecular properties of highly metastatic and...Show more In the past decade it became increasingly clear that tumor heterogeneity represents one of the major problems for cancer treatment, also in prostate cancer. The identification of the molecular properties of highly aggressive cells (Cancer Stem Cells, CSCs) dispersed within the tumor represents a challenge for the identification of new efficient therapies. In most of the cases, current treatments are indeed successful in eradicating the primary tumor. However, the clinical evidence of relapse and the occurrence of therapy resistance, suggest the presence of subpopulation of cells within the tumor, that can survive such treatments and can perpetuate the cancer. In this thesis we investigated the molecular properties of selected highly aggressive CSCs and indentified novel modulators responsible for the maintenance of their aggressive behavior. Collectively, the studies described in this thesis have increased our insights into the molecular properties of highly metastatic and tumorigenic prostate cancer stem-like cells and provided new targets for possible diagnostic and therapeutic applications.Show less
MicroRNA
Prostate cancer
Cancer stem cells
Ccripto
Bone metastasis
All authors
Zoni, E.
Supervisor
Pelger, R.C.M.
Co-supervisor
Pluijm, G. van der
Committee
Hoeben, R.C.; Cleton-Jansen, A.M.; Jenster, G.W.; Heymann, D.
Qualification
Doctor (dr.)
Awarding Institution
Medicine, Leiden University Medical Center (LUMC), Leiden University
Date
2016-06-02
ISBN (print)
9789090296524

Funding

Sponsorship
Printing of this thesis was kindly sponsored by Astellas, Sanofi-Aventis and Boehringer Ingelheim.