Pharmacotherapy and ventilatory control in health and disease

Simons, P. (2024)

Doctoral Thesis

The studies described in this thesis investigate the effects of different pharmacotherapies
on antinociception and ventilatory control. Additionally, inherent variabilities in patient phenotypes within the population were assessed to gain a deeper understanding of the individual effects of analgesics and the ventilatory effects of disease, particularly type 2 diabetes mellitus (T2DM).

• Ketamine
• Pain
• Antinociception
• Ventilatory depression
• Mu-opioid receptors
• Oliceridine
• Diabetes

• All authors: Simons, P.
• Supervisor: Dahan, A.
• Co-supervisor: Niesters, M.; Velzen, M. van
• Committee: Sarton, E.Y.; Karan, S.B.; Hollmann, M.W.; Pijl, H.; Swen, J.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2024-06-05
• ISBN (print): 9789465060958
• Sponsorship: ChipSoft; Trevena