Early detection of pancreatic cancer in high-risk individuals

Klatte, D.C.F. (2024)

Doctoral Thesis

Earlier detection of pancreatic cancer is necessary to improve its poor prognosis. Currently, screening of the general population is not feasible due to the relatively low lifetime risk. However, up to one in ten cases occur in individuals with a strong family history of germline mutation carriers, known as high-risk individuals (HRIs). For these HRIs, pancreatic cancer surveillance in expert centers is recommended. The first part of this thesis focuses on evaluating the effectiveness of pancreatic cancer surveillance in carriers of a germline CD2KNA/p16 mutation who have a very high lifetime risk of developing pancreatic cancer. The second part focuses on various aspects to improve pancreatic cancer surveillance programs, including the study of biomarkers, risk stratification, and assessment of psychosocial aspects. Finally, attention is given to the identification of individuals at increased risk from the general population.

• Pancreatic cancer
• Surveillance
• Early detection
• High-risk individuals
• Screening
• Germline mutation

• All authors: Klatte, D.C.F.
• Supervisor: Leerdam, M.E. van; Hooft, J.E. van
• Committee: Groenwold, R.H.H.; Asperen, C.J.van; Besselink, M.G.H.; Cahen, D.L.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2024-06-05
• ISBN (print): 9789464839609
• Sponsorship: Immunovia, Nederlandse Vereniging voor Gastroenterologie, Chipsoft, Viatris, ABN Amro, Tramedico