Optimizing immunotherapy in locoregional and metastatic urothelial cancer

Dijk, N. van (2024)

Doctoral Thesis

This thesis focuses on the outcome to immunotherapy in locoregional and metastatic urothelial cancer and biomarkers in the tumor-immune microenvironment that may inform outcome, ultimately enhancing cancer immunotherapy. Firstly, we discuss the outcome of urothelial cancer patients treated with checkpoint immunotherapy in the metastatic (Part I) and preoperative setting (Part II). Next, we focus on the UC tumor immune microenvironment (Part III), as this may facilitate the discovery and development of novel cancer immunotherapy as well as predictive biomarkers for immunotherapy response in UC. A comprehensive framework based on tumor- and host-specific parameters to better understand immunotherapy response in UC is also provided (Part III).

• Urothelial Cancer
• Immunotherapy
• Neoadjuvant
• Checkpoint inhibitors
• Biomarkers

• All authors: Dijk, N. van
• Supervisor: Haanen, J.B.A.G.
• Co-supervisor: Heijden, M.S. van der
• Committee: Blank, C.U.; Zuur, C.L.; Boormans, J.L.; Suelmann, B.B.M.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2024-01-16
• ISBN (print): 9789463619110