Gut environment and socioeconomic status: a study of children in urban area of Makassar

Amaruddin, A.I. (2023)

Doctoral Thesis

Although urbanization has long been associated with human development and progress,
recent research has revealed that urban environments can also result in significant inequalities
in many areas including health. In particular, urban areas in low and middle income
countries (LMIC), often see a widening gap in economic growth which contributes to health
disparities between wealthy and underprivileged children. Several studies have established
the association between socioeconomic status (SES) and child health, showing that children
of low-income parents had poorer health status. The rise of non-communicable diseases,
the persistence of communicable disease, and the challenge of re-emerging diseases are
currently a burden in developing countries. Given the rapid increases of urbanization and
urban poverty in several developing countries including Indonesia, it is important to elaborate
to what extent SES affects child health. We have done so, in relation to outcome of BCG
vaccination, atopic sensitization, and intestinal barrier function. We have also investigated
the interaction between intestinal parasitic infections and bacterial gut microbiota in order
to be able to delineate the contribution of this interaction on the function of intestinal barrier.

• Socioeconomic status
• Helminth infection
• Parasitic infection
• Allergy
• Hymenoptera venom allergy
• Gut microbiota
• Intestinal permeability
• BCG scar

• All authors: Amaruddin, A.I.
• Supervisor: Yazdanbakhsh, M.
• Co-supervisor: Sartono, E.; Hamid, F.
• Committee: Smits, H.H.; Ree, R. van; Adegnika, A.A.; Amoah, A.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2023-11-15
• ISBN (print): 9789493353237