Substrate identification and treatment of right ventricular tachycardia: scar patterns and novel mapping tools

Venlet, J. (2023)

Doctoral Thesis

This thesis aims to improve the understanding and identification of the ventricular tachycardia substrate in patients with right ventricular tachycardia. An isolated epicardial right ventricular outflow tract scar is described in high level endurance athletes. Novel parameters such as endocardial unipolar voltage, transmural activation time and CT heterogeneity may help to guide substrate mapping and ablation. Implementing these techniques in current clinical practice may improve the identification and treatment of ventricular tachycardia substrates in right ventricular cardiomyopathies.

• Ventricular tachycardia
• Arrhythmias
• Electrophysiology
• Endurance athletes
• Catheter mapping and ablation
• Arrhythmogenic right ventricular cardiomyopathy
• Computed tomography
• Epicardial fat
• VT-substrate
• Antiarrhythmic drug

• All authors: Venlet, J.
• Supervisor: Zeppenfeld, K.
• Co-supervisor: Piers, S.R.D.
• Committee: Blom, N.A.; Bootsma, M.; Groot, J.R. de; Riele, A.S.J.M. te; Schalij, M.J.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2023-09-07
• ISBN (print): 9789464694383
• Sponsorship: ABN AMRO bank; Abbott Medical Systems Nederland; Hart onderzoek Nederland; Nederlandse hartstichting