Healthy elderly in clinical trials: how to define preclinical Alzheimer’s Disease for clinical trial participation

Prins, S. (2023)

Doctoral Thesis

How to define the preclinical Alzheimer's Disease state in otherwise healthy elderly. How to best select otherwise healthy elderly for clinical trials participation with a disease modifiying compound. Difference between healthy elderly and subjects in the preclinical AD stage on biomarker level. Difference in cognitive performance in healthy subjects compared to neurodegenerative disease profiles.

• Preclinical Alzheimer's Diseases
• Neurodegeneration
• Healthy elderly
• Clinical trials
• Biomarkers
• Neuroinflammation

• All authors: Prins, S.
• Supervisor: Groeneveld, G.J.; Gerven, J.M.A. van
• Co-supervisor: Borghans, L.
• Committee: Middelkoop, H.; Teunissen, C.; Blauw, G.J.; Prins, N.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2023-04-05