Subamniotic hemorrhage, a possible new presentation of fetal and neonatal alloimmune thrombocytopenia

Giesbers, S.; Bos, M.; Bulten, J.; Meeren, L. van der; Drongelen, J. van (2022)

Article / Letter to editor

BackgrounBackground: Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare fetal disease in which maternal antibodies directed toward fetal human platelet antigens (HPA) are formed during pregnancy and cause fetal thrombocytopenia. The diagnosis FNAIT is suspected when a fetus or neonate presents with signs of bleeding. Case: We describe a pregnancy complicated by a placental hematoma in the 20th week of gestation as the first manifestation of FNAIT. Further evaluation showed signs of germinal matrix hemorrhage and HPA-5b allo-antibodies. After the diagnosis, intravenous immunoglobulin was administered weekly and a healthy daughter was born at 37 weeks. Histopathological analysis revealed that the hematoma was caused by a sub-amniotic hemorrhage of fetal origin. Conclusion: A subamniotic hematoma appears to be the first manifestation of FNAIT. (c) 2022 The Author(s). Published by S. Karger AG, Basel

• Human platelet antigens-5b
• Allo-antibodies
• Placenta
• Subamniotic
• Hematoma
• Fetal and neonatal alloimmune thrombocytopenia

• All authors: Giesbers, S.; Bos, M.; Bulten, J.; Meeren, L. van der; Drongelen, J. van
• Date: 2022-01-01
• Journal: Fetal Diagnosis and Therapy
• Volume: 49
• Issue: 1-2
• Pages: 60 - 64
• DOI: doi:10.1159/000521866
• Link: https://karger.com/fdt/article/49/1-2/60/823614/Subamniotic-Hemorrhage-a...