Unraveling genetic mechanisms in headache syndromes

Weller, C.M. (2015)

Doctoral Thesis

Migraine and cluster headache are disabling brain disorders. Current treatment is ineffective in many patients. The research performed in this thesis aimed at elucidating some of the molecular genetic mechanisms in these two headache disorders by means of clinical and genetic studies in complex and/or monogenic forms of these diseases and related disorders. Knowledge from studies like these could be used to the benefit of patients by improving clinical diagnoses and/or by providing useful drug targets for future drug development strategies.

• Alternating hemiplegia of childhood
• Familial hemiplegic migraine
• Cluster headache
• Migraine

• All authors: Weller, C.M.
• Supervisor: Maagdenberg, A.M.J.M. van den; Ferrari, M.D.
• Co-supervisor: Terwindt, G.M.
• Qualification: Doctor (dr.)
• Awarding Institution: Department of Human Genetics, Faculty of Medicine (LUMC), Leiden University
• Date: 2015-09-02
• ISBN (print): 9789461825858