Refining individualized medicine in older patients with breast cancer

Boer, A.Z. de (2022)

Doctoral Thesis

Due to a shorter remaining life expectancy, the risk of recurrence in older patients with low risk breast cancer is often reduced and the benefit of treatments may be very limited, especially with adjuvant treatments. In the first part of this thesis, we studied the interplay between breast cancer mortality and other-cause mortality. In the second part of this thesis, we investigated the effect of surgery and radiotherapy in subsets of the older population of patients with breast cancer in which the actual treatment effect is questionable.

• Breast cancer
• Geriatric oncology
• Older patients
• Other-cause mortality
• Competing mortality
• Instrumental variable analysis
• Population-based
• Radiotherapy after breast-conserving surgery
• Primary endocrine therapy
• Absolute risks
• Prediction models

• All authors: Boer, A.Z. de
• Supervisor: Portielje, J.E.A.
• Co-supervisor: Bastiaannet, E.; Liefers, G.J.
• Committee: Boersma, L.J.; Putter, H.; Siesling, S.; Vrancken Peeters, M.J.T.F.D.; Wildiers, H.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2022-10-26
• Sponsorship: ZonMw