Immune modulation and monitoring of cell therapy in inflammatory disorders

Suwandi, J.S. (2022)

Doctoral Thesis

The immune system consists of a complex network that protects the body from pathogens and cancer. Autoimmune diseases and inflammatory conditions are caused by a disturbed and unbalanced immune system in which the body's own cells are destroyed by immune cells as a result of an inflammatory reaction. In this thesis, I focused on type 1 diabetes as an autoimmune disease to investigate the derailment of the immune system and explored strategies involving cell therapy with tolerogenic
dendritic cells to restore immune tolerance. In addition, I studied the application of cell therapy in other inflammatory disorders such as rheumatoid arthritis and graft-versus-host disease.

• Immune modulation
• Cell therapy
• Tolerogenic dendritic cells
• Mesenchymal stromal cells Immune monitoring
• Regulatory T-cells
• Mass cytometry

• All authors: Suwandi, J.S.
• Supervisor: Roep, B.O.; Zwaginga, J.J.
• Co-supervisor: Nikolic, T.
• Committee: Lankester, A.C.; Staal, F.J.T.; Koning, E.J.P. de; Kooyk, Y. van; Rodriguez-Calvo, T.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2022-10-18
• ISBN (print): 9789464238976