Pro-resolving fatty acids and oxylipids in osteoarthritis and rheumatoid arthritis

Brouwers, H. (2022)

Doctoral Thesis

The studies described in this thesis provides the field with valuable data on the potential therapeutic effects of fatty acids and specialized pro-resolving lipid mediators in rheumatoid arthritis and osteoarthritis. The omega-6 fatty acid AdA shows potent pro-resolving effects on the production of pro-inflammatory chemoattractant
LTB4 with great promise to limit RA disease progression. In contrast to the promising potential therapeutic effects of AdA in RA, the evidence for pro-resolving effects in OA is still scarce. The results of the studies from this thesis show that neither LXA4, LXB4, RvE2 or Mar-1 were able to reduce OA disease activity in the experimental set-up we used. Finally, the studies described in this thesis show the utmost critical importance of the right sample preparation and storage for the intended subsequent analysis.

• Rheumatoid arthritis
• Osteoarthritis
• Specialized pro-resolving lipid mediators
• Synovial fluid
• Fatty acids
• Lipidomics

• All authors: Brouwers, H.
• Supervisor: Toes, R.E.M.; Kloppenburg, G.
• Co-supervisor: Ioan-Facsinay, A.
• Committee: Huizinga, T.W.J.; Meulenbelt, I.; Meurs, J.B.J. van; Mastbergen, S.C.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2022-09-20
• ISBN (print): 9789464583038