Functions of leptin in tuberculosis and diabetes: multi-omics studies across species

Ding, Y. (2021)

Doctoral Thesis

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models. 3) how tuberculosis infection and resulting metabolic reprogramming are dependent on leptin signaling in mice and zebrafish larvae.

• Tuberculosis
• Diabetes
• Leptin
• Omics
• Metabolomics
• Transcriptomics
• Mice
• Zebrafish

• All authors: Ding, Y.
• Supervisor: Spaink, H.P.; Alia, A.
• Committee: Wezel, G.P. van; Meijer, A.H.; Hankemeier, T.; Matysik, J.; Berry, J.P.
• Qualification: Doctor (dr.)
• Awarding Institution: Institute of Biology Leiden (IBL), Faculty of Science, Leiden University
• Date: 2021-12-07
• ISBN (print): 9789492597854