Coiled-coil biomaterials for biological applications

Shen, M. (2021)

Doctoral Thesis

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion. By knowledge-guideddesign and modification, coiled-coil induced membrane fusion systems are expected to achieve drug delivery in vivo. Finally, L-forms obtained by coiled-coil induced fusion of different strains are expected to be an ideal model for studying questions related to the origin of life and novel antibiotics.

• Coiled-coil peptides
• Biomaterials
• Membrane fusion
• Cell sorting
• Cell-cell fusion
• Fusogenicity

• All authors: Shen, M.
• Supervisor: Kros, A.
• Co-supervisor: Boyle, A.L.
• Committee: Overkleeft, H.S.; Schneider, G.F.; Kieltyka, R.E.; Claessen, D.; Santos, H.A.; Reek, J.N.H.
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University
• Date: 2021-11-24