Dyslipidemia at the crossroad of the skin barrier and the arterial wall

Martins Cardoso, R. (2021)

Doctoral Thesis

The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule in liposomal formulations to deliver liver X receptor agonist to plaque resident foam cells/lipid-rich macrophages. Elucidation of the mechanisms underlying the intercommunication between plasma lipids and skin lipids may also bring valuable opportunities to prevent and treat dermatological pathologies in dyslipidemic patients; perhaps in combination with anti-atherogenic therapies. Thus, by deepening our knowledge we may improve our advice to the patients and ultimately improve their quality of life.

• Hypercholesterolemia
• Free fatty acids
• Skin lipids
• Skin barrier
• Mice
• Lyp-1
• Atherosclerosis
• Liposomes
• Liver X receptor

• All authors: Martins Cardoso, R.
• Supervisor: Bouwstra, J.A.
• Co-supervisor: Eck, M. van
• Committee: Irth, H.; Kuiper, J.; Smeden, J. van; Rensen, P.C.N.; Vermonden, T.; Mulder, T.
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden Academic Centre for Drug Research (LADCR), Faculty of Science, Leiden University
• Date: 2021-10-05
• ISBN (print): 9789464214666