The aorta in transposition of the great arteries

Palen, R.L.F. van der (2021)

Doctoral Thesis

The thesis summarizes the results on the prevalence and evolution of neo-aortic root pathology and surgical cardiovascular outcomes in patients after arterial switch operation (ASO) for transposition of the great arteries. Furthermore, thoracic aortic blood flow hemodynamics were investigated in relation to post-ASO geometry and root pathology with advanced non-invasive four-dimensional flow cardiovascular magnetic resonance imaging techniques.

• Transposition of the great arteries
• Congenital heart disease (CHD)
• Arterial switch operation (ASO)
• Neo-aortic dilatation
• Neo-aortic valve insufficiency
• 4D flow MRI
• Wall shear stress
• Aortopathy
• Outcome

• All authors: Palen, R.L.F. van der
• Supervisor: Blom, N.A.; Hazekamp, M.G.
• Co-supervisor: Roest, A.A.W.
• Committee: Lamb, H.J.; François, K.; Helbing, W.A.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2021-06-16
• ISBN (print): 9789464232752
• Sponsorship: Dutch Heart Foundation (DHF grant number 2014T087); Willem Alexander Children's Hospital; Pie Medical Imaging B.V.