Investigations on the role of impaired lysosomes of macrophages in disease

Lienden, M.J.C. van der (2021)

Doctoral Thesis

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling. Novel imaging and labelling techniques are applied to provide in depth characterization of lysosome function in health and disease. An integrative approach was used to study the physiological role of the lysosome, characterizing the function of lysosomal hydrolases and signalling on a cellular level as well as within the context of tissue.

• Lipid-laden macrophage
• Gaucher disease
• Glucocerebrosidase
• Activity-based probes
• Lysosomal storage disorder
• Obesity
• Lysosome biogenesis
• Transcription factors
• Biomarkers
• Low-grade inflammation

• All authors: Lienden, M.J.C. van der
• Supervisor: Aerts, J.M.F.G.
• Co-supervisor: Eijk, M. van
• Committee: Cox, T.M.; Eck, M. van; Laman, J.D.; Overkleeft, H.S.; Stelt, M. van der
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University
• Date: 2021-03-18
• ISBN (print): 9789464212280