Targeting the brain under stress : selective glucocorticoid receptor modulation

Zalachoras, I. (2014)

Doctoral Thesis

In this thesis studies are reported aimed to modulate the function of the GR by targeting GR-coregulator interactions. To achieve this goal, we used two different approaches. Firstly, we manipulated the splicing of SRC-1 with antisense oligonucleotides (AONs) administered in the CeA to change the relative expression of the two SRC-1 splice variants. Secondly, we used two novel GR ligands that allowed certain GR-coregulator interactions while preventing others, thus resulting in a mixed GR-coregulator interaction profile, which exhibited a spectrum of both agonist and antagonist activities

• Central amygdala
• Glucocorticoid receptor
• steroid receptor coregulator-1
• Stress
• CRH

• All authors: Zalachoras, I.
• Supervisor: Meijer, O.C.
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden University Medical Center (LUMC), Leiden University
• Date: 2014-09-17
• ISBN (print): 9789461824806