Leiden University Scholarly Publications

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Ewing, M.M. (2013)

Post-interventional atherosclerotic vascular remodeling : preclinical investigation into immune-modulatory therapies

Doctoral Thesis
Cardiovascular diseases remain the major cause of death throughout the world and can be primarily attributed to atherosclerotic vascular disease leading to stroke and coronary heart disease (CHD). Improved primary prevention and the introduction and subsequent optimization of percutaneous coronary interventions (PCI) for myocardial ischemia due to obstructive CHD have significantly improved patient outcome and reduced morbidity and mortality. The insight into disease pathology has however expanded tremendously over the past decade and continuing research has shifted the focus of interest towards post-interventional accelerated atherosclerosis development due to a dysfunctional (auto) immune inflammatory response, responsible for vascular remodeling, re-occlusion and recurrence of symptoms. The aim of this thesis therefore was to investigate the role of the immune system in this pathophysiological process that ultimately results in post-interventional atherosclerotic vascular...Show moreCardiovascular diseases remain the major cause of death throughout the world and can be primarily attributed to atherosclerotic vascular disease leading to stroke and coronary heart disease (CHD). Improved primary prevention and the introduction and subsequent optimization of percutaneous coronary interventions (PCI) for myocardial ischemia due to obstructive CHD have significantly improved patient outcome and reduced morbidity and mortality. The insight into disease pathology has however expanded tremendously over the past decade and continuing research has shifted the focus of interest towards post-interventional accelerated atherosclerosis development due to a dysfunctional (auto) immune inflammatory response, responsible for vascular remodeling, re-occlusion and recurrence of symptoms. The aim of this thesis therefore was to investigate the role of the immune system in this pathophysiological process that ultimately results in post-interventional atherosclerotic vascular remodeling and apply this insight for the development of new immune-modulatory therapies in a preclinical setting.Show less
PCAF
Epigenetics
Co-stimulation
Toll-like receptors
Phosphorylcholine
Annexin A5
Biomarkers
Inflammation
Restenosis
Atherosclerosis
All authors
Ewing, M.M.
Supervisor
Quax, P.H.A.
Co-supervisor
Jukema, J.W.
Qualification
Doctor (dr.)
Awarding Institution
Leiden University Medical Center (LUMC), Leiden University
Date
2013-05-23
ISBN (print)
9789462033313

Funding

Sponsorship
Boehringer Ingelheim BV Boston Scientific ChipSoft Daiichi Sankyo Nederland BV Diabetes Fonds J.E. Jurriaanse Stichting Nederlandse Hartstichting MSD Nederland BV Roche Nederland BV Servier Nederland Farma BV