Hydrogel based drug carriers for controlled release of hydrophobic drugs and proteins

Ke, P. (2011)

Doctoral Thesis

The aim of this study is to prepare in situ forming hydrogels based on biocompatible polymers for the controlled release of hydrophobic drug and proteins. In order to load hydrophobic drug to the hydrophilic hydrogel matrix, beta-cyclodextrin and human serum albumin was introduced to the hydrogel network respectively and acted as the primary accommodation for those hydrophobic molecules within the hydrogel network. Furthermore, supramolecular crosslinked and covalently crosslinked light sensitive hydrogels were prepared whose potential application for light controlled protein release system has been shown.

• Protein
• Light sensitivity
• Hydrophobic drug
• Hydrogel
• Drug delivery
• Controlled release

• All authors: Ke, P.
• Supervisor: Fraaije, J.G.E.M.
• Co-supervisor: Kros, A.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Science, Leiden University
• Date: 2011-09-14
• ISBN (print): 9789085707820